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To turn on potentially unwanted app blocking go to Start > Settings > Update & Security > Windows Security > App & browser control > Reputation-based protection settings. There you'll find a control that lets you turn potentially unwanted app blocking on, and select if you want to block apps, downloads, or both.

The potentially unwanted application (PUA) protection feature in Microsoft Defender Antivirus can detect and block PUA on endpoints in your network.

For a description of the criteria used to classify software as a PUA, see Potentially unwanted application. Protect against PUA with Microsoft Edge. Microsoft Edge (version 80.0.361.50 or later) blocks PUA downloads and associated resource URLs. You can set up protection by enabling the Block potentially unwanted apps feature in Microsoft Edge.

Cloud App Security enables you to block access to unsanctioned apps by using your existing on-prem security appliances. You can generate a dedicated block script and import it to your appliance. This solution doesn't require redirection of all of the organization's web traffic to a proxy.